Glucose-6-phosphate dehydrogenase (G6PDH)

Glucose 6 phosphate dehydrogenase deficiency (G6PD) deficiency yog ib hom kab mob uas cov qe ntshav liab tawg (hemolysis) thaum lub cev raug rau qee yam zaub mov, tshuaj, kab mob lossis kev ntxhov siab.Nws tshwm sim thaum ib tus neeg ploj lawm lossis tsis muaj cov enzyme glucose-6-phosphate dehydrogenase.Cov enzyme no pab cov qe ntshav liab ua haujlwm zoo.Cov tsos mob thaum lub sij hawm hemolytic tuaj yeem muaj xws li zis tsaus nti, qaug zog, daj ntseg, lub plawv dhia ceev, ua tsis taus pa, thiab daj ntawm daim tawv nqaij (jaundice).G6PD tsis muaj peev xwm tau txais txiaj ntsig los ntawm X-txuas rov qab zoo li qub thiab cov tsos mob tshwm sim ntau dua hauv cov txiv neej (tshwj xeeb yog cov neeg Asmeskas Asmeskas thiab cov neeg los ntawm qee qhov chaw ntawm Africa, Asia, thiab Mediterranean).Nws yog tshwm sim los ntawm kev hloov caj ces hauv G6PD gene.

Glucose-6-Phophate Dehydrogenase (G-6-PDH) muaj ob lub subunits ntawm qhov sib npaug ntawm qhov hnyav molecular.Cov amino acid sib lawv liag ntawm cov monomer tau raug luam tawm.G-6-PDH tau siv rau hauv kev soj ntsuam rau nicotinamide adenine dinucleotide thiab cov ntaub so ntswg pyridine. nucleotides.G-6-PDH tuaj yeem rov ua haujlwm los ntawm cov tshuaj urea-denatured.

Glucose 6-phosphate dehydrogenase yog ib qho tseem ceeb tswj enzyme nyob rau hauv thawj kauj ruam ntawm txoj kev pentose phosphate.G-6-P-DH oxidizes qabzib-6-phosphate nyob rau hauv lub xub ntiag ntawm NADP⁺ 6-phosphogluconate yield.Polyacrylamide gel electrophoresis, kev ua staining, thiab tiv thaiv cov poov xab G-6- PDH antibody immunoblotting kev tshawb fawb tau qhia tias G-6-PDH yog glycoprotein.