Tranexamic Acid (1197-18-8)
Product Description
● Tranexamic Acid (1197-18-8)
CAS Nr.: · 1197-18-8
● EINECS No.: 356.2222
● MF: C8H15NO2
● Pob: 25Kg / Nruas
● Tranexamic acid (TXA) yog cov tshuaj siv los kho lossis tiv thaiv kev poob ntshav ntau dhau los ntawm kev raug mob loj, ntshav tom qab yug me nyuam, kev phais, kev tshem tawm hniav, qhov ntswg, thiab kev coj khaub ncaws hnyav.[2][3]Nws kuj yog siv rau kev kho mob angioedema.Nws yog noj los ntawm qhov ncauj los yog txhaj tshuaj rau hauv cov hlab ntsha.
Mechanism ntawm kev ua
Tranexamic acid yog ib qho hluavtaws analog ntawm cov amino acid lysine.Nws ua hauj lwm raws li ib tug antifibrinolytic los ntawm reversibly khi plaub mus rau tsib lysine receptor chaw ntawm plasminogen.Qhov no txo qis kev hloov pauv ntawm plasminogen rau plasmin, tiv thaiv fibrin degradation thiab khaws cia lub moj khaum ntawm fibrin's matrix qauv.Tranexamic acid muaj kwv yees li yim npaug ntawm cov tshuaj antifibrinolytic ntawm cov laus analogue, ε-aminocaproic acid. kev ua ntawm plasmin nrog tsis muaj zog potency (IC50 = 87 mM), thiab nws tuaj yeem thaiv qhov chaw ua haujlwm ntawm urokinase plasminogen activator (uPA) nrog cov ntsiab lus siab (Ki = 2 mM), yog ib qhov siab tshaj ntawm tag nrho cov serine proteases.
Tranexamic acid ua haujlwm
Tranexamic acid feem ntau siv tom qab kev raug mob loj.[13]Tranexamic acid yog siv los tiv thaiv thiab kho cov ntshav poob hauv ntau yam xwm txheej, xws li cov txheej txheem kho hniav, kev coj khaub ncaws hnyav hnyav, thiab kev phais mob uas muaj kev pheej hmoo ntawm ntshav poob.
| Cov khoom xeem | Pharmacopeial Criteria | Kev Xeem | |
| CEEB TOOM | Cov tsos mob: Dawb los yog yuav luag dawb, crystalline hmoov | Dawb crystalline hmoov | |
| Solubility: Dawb soluble nyob rau hauv dej thiab nyob rau hauv glacial acetic acid, xyaum insoluble nyob rau hauv acetone thiab ethanol (96%) | Hla | ||
| IDENTIFICATION | Infrared Absorption Spectrophotometry: IR spectrum yog concordance nrog Tranexamic acid CRS | Hla | |
| TEST | pH (2,2.3) | 7.0-8.0 Nws | 7.4 ib |
| Yam Khoom Muaj (HPLC2.2.29) | impurity A≤ 0.1% | Tsis Pom | |
| impurity B≤ 0.2% | 0.03% | ||
| Cov impuritiesC Unspecified impurities≤ 0.10% Impurities D Lwm yam impurities | 0.002% 0.001% Tsis Pom | ||
| Cov ntsiab lus ntawm cov impurities tsis qhia meej ≤ 0.2% | 0.003% | ||
| Halides nthuav tawm raws li chlorides | ≤140ppm | <140ppm | |
| Poob rau ziab | ≤ 0.5% | 0.026% | |
| Sulfated tshauv | ≤0.1% | 0.027% | |
| QHIA | Yuav tsum nyob rau hauv (Rau raws) 99.0% ~ 101.0% | 100.1% | |
