Gliclazide (21187-98-4)
Cov npe khoom
Gliclazide yog ib qho tshuaj sulfonylurea qhov ncauj antidiabetic tshuaj.Nws yog dawb crystalline los yog crystalline hmoov, tsw tsw thiab saj.
Gliclazide yog 2 tiam ntawm qhov ncauj sulfonylurea hypoglycemic tus neeg saib xyuas nrog kev ua haujlwm muaj zog.Nws cov txheej txheem zoo ib yam li toluenosulfonylurea, piv txwv li, nws xaiv ua haujlwm ntawm pancreatic β-hlwb los txhawb cov insulin tso tawm thiab txhim kho insulin tso tawm tom qab noj cov piam thaj, uas tuaj yeem tsis tsuas yog txhim kho cov metabolism hauv cov neeg mob ntshav qab zib, tab sis kuj txhim kho lossis ncua qhov tshwm sim ntawm qhov tshwm sim. ntshav qab zib vascular teeb meem.
Gliclazide feem ntau yog siv rau mob me thiab mob ntshav qab zib hom II mob ntshav qab zib mellitus nrog rau cov neeg laus pib qhov kev noj zaub mov thiab kev tawm dag zog ib leeg tsis muaj txiaj ntsig thiab tsis muaj kev nyiam rau ketosis, thiab tseem txhim kho cov kab mob ntawm cov kab mob thiab cov kab mob metabolic thiab vascular dysfunctions hauv cov neeg mob ntshav qab zib.
Daim ntawv thov
Gliclazide yog siv rau kev tswj hwm ntawm hyperglycemia hauv gliclazide-responsive diabetes mellitus ntawm kev ruaj khov, mob me, tsis-ketosis nquag, hom 2 mob ntshav qab zib.Nws yog siv thaum mob ntshav qab zib tsis tuaj yeem tswj hwm los ntawm kev tswj hwm kev noj zaub mov kom zoo thiab kev tawm dag zog lossis thaum kho cov tshuaj insulin tsis tsim nyog.
| Kuaj | Specifications | Cov txiaj ntsig ntawm kev txheeb xyuas |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov. | Dawb hmoov |
| Solubility | Xyaum insoluble hauv dej;dawb soluble nyob rau hauv methylene chloride;sparingly soluble hauv acetone;me ntsis soluble hauv ethanol (96 feem pua). | Ua tau raws li qhov yuav tsum tau ua |
| Cov cim | Infrared absorption spectrum yog concordant nrog uas tau nrog gliclazide CRS. | Ua tau raws li qhov yuav tsum tau ua |
| Impurity B (los ntawm HPLC) | ≤ 2 ppm | 0 ,5ppm |
| Cov hlau hnyav | ≤10ppm | <10ppm |
| Lwm yam tshuaj (los ntawm HPLC) | impurity F ≤0.1% | Tsis kuaj pom |
| Txhua qhov tsis meej impurity ≤0.10% | 0.04% | |
| Cov ntsiab lus ntawm impurities uas tsis yog F ≤0.2% | 0.11% | |
| Poob rau ziab | ≤ 0.25% | 0.11% |
| Sulfated tshauv | ≤0.1% | 0.03% |
| Residual solvents (Los ntawm GC) | Ethyl acetate NMT 2500 ppm | 265ppm ua |
| N, N-Dimethylformamide NMT 880 ppm | Tsis kuaj pom | |
| Assay | 99.0-101.0%, ntawm qhuav hauv paus. | 100.0% |
| Xaus | Cov txiaj ntsig kev xeem ua raws li EP8. | |
